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. 2021 Nov 11;11:22037. doi: 10.1038/s41598-021-01549-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunogenicity study of Vi-ΔVP8* for anti-ΔVP8*. (A) IgG of mice immunized with ΔVP8* or Vi-ΔVP8* conjugates. (B) percentage contribution of IgG subclasses to total IgG against ΔVP8*. (C) Neutralization analysis of sera from immunized mice; Day 42 immune sera for titers were used. BALB/c mice were immunized S.C. with 5 μg of Vi-ΔVP8*-P[4], P[6] or P[8], or 15 μg of multivalent formulation based on Vi polysaccharide, 3 times at 2-week intervals as described in Methods. Data were analyzed and illustrated using GraphPad Prism 6.0 software (GraphPad, https://graphpad.com); data are mean±s.d.; two sample t-test; *P<0.05, **P<0.01, *** P<0.001.