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Calculated Lipinski’s rule of five for tested compounds 4a–h.
| C. no. | TPSA | MW | cLogP | nHBA | nHBD | RB |
|---|---|---|---|---|---|---|
| 4a | 57.97 | 258 | 2.28 | 3 | 0 | 2 |
| 4b | 57.97 | 272 | 2.62 | 3 | 0 | 2 |
| 4c | 57.97 | 337 | 3.00 | 3 | 0 | 2 |
| 4d | 57.97 | 276 | 2.38 | 3 | 0 | 2 |
| 4e | 67.20 | 288 | 2.21 | 4 | 0 | 3 |
| 4f | 67.20 | 288 | 2.21 | 4 | 0 | 3 |
| 4g | 57.97 | 327 | 3.49 | 3 | 0 | 2 |
| 4h | 86.21 | 264 | 2.15 | 3 | 0 | 2 |
TPSA Total polar surface area, MW molecular weight, cLogP calculated lipophilicity, nHBA number of hydrogen bond acceptors, nHBD number of hydrogen bond donors, RB rotatable bonds.
