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. 2021 Oct 29;14:747855. doi: 10.3389/fnmol.2021.747855

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Copyright © 2021 Victor, Donaldson, Johnson, Miller and Reiter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Social Communication Questionnaire (SCQ) scores across all subjects. (A) SCQ scores across all subjects. (B) SCQ scores across individuals used for RNAseq analysis. A cutoff score of 15 (red line) is used as a threshold for “possible ASD.” The PW-UPD cohort has two segregated groups. Subjects that meet the criteria for “Possible ASD” (score of 15 or above) and those scoring within normal limits. For 2 of the neurotypical control subjects used, SCQs could not be collected. Significance testing was performed by one-way ANOVA testing. ** = p-value ≤ 0.01, *** = p-value ≤ 0.005.