Figure 2.

(A) Prevalence of hyponatremia in the studied ALL cohort: a considerable group of ALL patients showed statistically significant hyponatremia during induction therapy (solid line, ± standard deviation) compared to the rest of the ALL cohort (dashed line), which remained within the standard range of sodium in childhood (132–145 mmol/l). The start of the first hyponatremic episode was on average between days 27 and 28 (average day 27.6, curly brackets), although there was a statistically significant difference between hyponatremic and non-hyponatremic patients from day 12 (p = 0.014, F test and T test, curly brackets). (B) Mean sodium levels of all patients with the following diagnoses during the first 40 days of their initial therapy. Patients with Hodgkin’s lymphoma, Ewing sarcoma, Wilms tumor, benign brain tumors, and Langerhans cell histiocytosis do not show hyponatremia during therapy with alkaloids (sodium levels within standard range).