Table 3.

Risk of gastroduodenal bleeding or overall gastrointestinal complications according to the NSAID administered

NSAID	CNT Collaboration meta-analysis [26]a	Van Walsem et al. [20]b
Ibuprofen	3.63 (1.09–12.12)	0.5 (0.3–0.9)
Diclofenac	2.20 (1.06–4.54)	-
Naproxen	5.49 (2.74–10.99)	0.3 (0.2–0.6)
Coxibsc	2.22 (1.16–4.23)	-
Celecoxib	-	1.4 (0.8–2.3)
Eterocoxib	-	1.5 (1.3–1.9)

coxibs Cyclooxygenase 2 (COX-2)-selective NSAIDs, CNT Coxib and Traditional NSAID Trialists

^aData are expressed as rate ratio (RR) with the 95% confidence interval (CI) in parentheses vs. placebo

^bData refers to major GI events, not only bleeding, which are expressed as the RR with the 95% CI in parentheses vs. diclofenac (i.e., a RR < 1 favors diclofenac and > 1 favors the comparator)

^cCelecoxib, etoricoxib, rofecoxib, lumiracoxib