. 2021 Apr 19;10(2):783–808. doi: 10.1007/s40122-021-00260-1

Table 5.

Indications on the selection of the most adequate NSAID according to the cardiovascular and gastrointestinal risk, in patients with low renal risk

Low renal risk
CV risk	GI risk
CV risk	Low	High
Low	Diclofenac Coxib Ibuprofen Naproxen	Diclofenac + PPI Coxib + PPI Ibuprofen + PPI^a Naproxen + PPI
High	Naproxen Diclofenac Coxib Ibuprofen	Any NSAID
High + LDA	Diclofenac^b Coxib Ibuprofen Naproxen	Any NSAID

In italics, compounds indicated based on the available randomized controlled trials. Underlined, compounds contraindicated based on the available randomized controlled trials

GI gastrointestina, PPI proton-pump inhibitor, CV cardiovascular, NSAID non-steroidal anti-inflammatory drug, LDA low-dose aspirin

^aUp to 1200 mg per day

^bUse only if NSAID therapy is strictly necessary, and for a limited period of time