| The goal of treatment in osteoarthritis is to alleviate inflammatory pain and improve physical function through non-pharmacological and pharmacological interventions. |
| Therapy selection is hampered by older age, comorbidities and polypharmacy. |
| This narrative review addresses all phases of the patient journey from a multidisciplinary perspective, focusing on the safety of non-steroidal anti-inflammatory drugs. |
| We provide practical indications for general practitioners and specialists managing patients with osteoarthritis who suffer from chronic inflammatory pain. |
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