Table 4.
Changes in the clinical data in 63 patients who were given etanercept for 6 months
| PDQ ≤ 12 (n = 32) | PDQ > 12 (n = 31) | Overall | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline phase | After drug administration | P value | Baseline phase | After drug administration | P value | Baseline phase | After drug administration | P value | |
| PDQ | 4.34 ± 2.47 | 4.59 ± 2.79 | 0.5076 | 17.06 ± 2.40 | 15.55 ± 3.69 | 0.0059** | 10.60 ± 6.85 | 9.98 ± 6.40 | 0.0671 |
| NP | 2.85 ± 3.41 | 1.63 ± 1.88 | 0.0044** | 6.61 ± 5.20 | 3.42 ± 2.30 | < 0.0001**** | 4.70 ± 4.75 | 2.49 ± 2.26 | < 0.0001**** |
| TBP | 2.62 ± 3.11 | 1.73 ± 1.85 | 0.0120* | 7.01 ± 3.32 | 3.32 ± 2.30 | < 0.0001**** | 4.78 ± 5.04 | 2.50 ± 2.21 | < 0.0001**** |
| PP | 1.55 ± 2.28 | 1.25 ± 1.95 | 0.2161 | 3.23 ± 2.63 | 1.72 ± 2.40 | < 0.0001**** | 2.38 ± 2.58 | 1.48 ± 1.99 | < 0.0001**** |
| CRP | 12.92 ± 17.23 | 7.40 ± 11.47 | 0.0017** | 14.98 ± 10.88 | 6.41 ± 3.91 | < 0.0001**** | 13.93 ± 14.38 | 6.91 ± 8.56 | < 0.0001**** |
| BASDAI | 1.88 ± 1.66 | 1.56 ± 1.46 | 0.1902 | 4.39 ± 1.89 | 2.74 ± 1.40 | < 0.0001**** | 3.12 ± 2.17 | 2.14 ± 1.54 | < 0.0001**** |
| ASDAS | 1.43 ± 0.90 | 1.02 ± 0.09 | 0.0007*** | 2.33 ± 0.74 | 1.59 ± 0.80 | < 0.0001**** | 1.87 ± 0.94 | 1.30 ± 0.79 | < 0.0001**** |
| HAQ | 1.87 ± 1.33 | 0.86 ± 0.88 | 0.0001**** | 2.27 ± 1.47 | 1.51 ± 1.13 | < 0.0001**** | 2.07 ± 1.40 | 1.18 ± 1.05 | < 0.0001**** |
| HAD-A | 4.43 ± 3.32 | 2.87 ± 2.89 | 0.0009*** | 6.74 ± 2.97 | 4.80 ± 3.02 | 0.0004**** | 5.57 ± 3.33 | 3.82 ± 3.09 | < 0.0001**** |
| HAD-D | 6.00 ± 3.44 | 4.00 ± 2.79 | 0.0016** | 7.19 ± 3.26 | 4.74 ± 3.01 | < 0.0001**** | 5.73 ± 7.43 | 3.63 ± 5.09 | < 0.0001**** |
| BASDAI-fatigue | 2.57 ± 2.49 | 1.79 ± 1.84 | 0.0316* | 3.77 ± 5.43 | 2.87 ± 4.51 | 0.0143* | 2.92 ± 4.22 | 2.16 ± 3.29 | 0.001** |
Data are expressed as the mean ± standard deviation (SD); P value represents comparison before and after drug administration, ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05
PDQ pain detection questionnaire, NP nocturnal pain, TBP total back pain, PP peripheral pain, CRP C-reactive protein, ASDAS-CRP ankylosing spondylitis disease activity score-CRP, BASDAI bath assessment of ankylosing spondylitis disease activity index, HAQ health assessment questionnaire, HAD-A hospital anxiety and depression scale-anxiety, HAD-D hospital anxiety and depression scale-depression