Table 5.
Changes of neurotransmitter concentrations in peripheral blood of 20 AS patients and ten healthy controls
| PDQ > 19 (n = 6) | PDQ ≤ 19 (n = 14) | Control (n = 10) | P | |
|---|---|---|---|---|
| Sex (M/F) | 4/2 | 13/1 | 8/2 | 0.3338 |
| Age | 42.67 ± 4.27 | 36.57 ± 2.72 | 0.21 ± 0.06 | 0.2394 |
| Duration | 18.67 ± 2.47 | 11.94 ± 2.19 | 0.0887 | |
| CRP | 5.02 ± 2.60 | 8.09 ± 6.79 | 0.3028 | |
| BASDAI | 4.27 ± 1.89 | 2.15 ± 1.17 | 0.0064** | |
| NE | 0.21 ± 0.06 | 0.13 ± 0.05 | 0.07 ± 0.02 | < 0.001*** |
| 5HT | 22.62 ± 9.65 | 20.50 ± 17.85 | 19.96 ± 10.01 | 0.9338 |
| Gly | 110.8 ± 21.37 | 96.61 ± 25.24 | 95.32 ± 34.52 | 0.5223 |
| Glu | 16.64 ± 7.32 | 29.83 ± 29.05 | 19.66 ± 5.05 | 0.3277 |
| GABA | 587.7 ± 19.01 | 629.0 ± 336.0 | 523.4 ± 135.4 | 0.6213 |
| 5HIAA | 2.21 ± 0.97 | 3.97 ± 3.87 | 2.62 ± 0.67 | 0.3277 |
| KYN | 78.35 ± 25.35 | 83.87 ± 44.80 | 69.79 ± 18.05 | 0.4845 |
| TRP | 1,860 ± 402.7 | 2,067 ± 482.0 | 2,008 ± 446.7 | 0.6528 |
Data are expressed as the mean ± standard deviation (SD); P value represents comparison between the three groups, ***P < 0.001, **P < 0.01, *P < 0.05
CRP C-reactive protein, BASDAI bath assessment of ankylosing spondylitis disease activity index, NE norepinephrine, 5HT serotonin, Gly glycine, Glu glutamic acid, GABA γ-aminobutyric acid, 5HIAA 5-hydroxyindoleacetic acid, KYN kynurenine, TRP tryptophan