Table 1.
Factors influence HBV persistence in HDI mouse model.
| Authors | Mouse background/gender/age | Plasmid backbone, dosage | Persistent of HBV antigens or replicative intermediates |
|---|---|---|---|
| Yang et al. ( 12 ) | B10.D2 and CB17 NOD/Scid (6-9 weeks) | 13.5 μg pT-MCS-HBV1.3 and 4.5 μg pCMV-SB | HBsAg, HBeAg disappeared at 7 dpi; HBcAg 1 dpi (6%), 7 dpi (4%) |
| Huang et al. ( 13 ) | C57BL/6 (male, 6-8 weeks) | 10 μg, pAAV/HBV1.2 | 80% mice HBsAg positive at week 5; 40% HBsAg positive > 6 month; replicative intermediates remained detectable at 22 dpi |
| BALB/c (male, 6-8 weeks) | 10 μg, pAAV/HBV1.2 | HBsAg disappeared from week 2; replicative intermediates decreased from 14 dpi | |
| C57BL/6 (male, 6-8 weeks) | 10 μg, pGEM4Z/HBV1.2, | HBsAg disappeared within 3 weeks | |
| Li et al. ( 14 ) | C57BL/6 (male, 6-8 weeks) | 15 μg pAAV/HBV1.3, pcDNA3.1(+)-HBV1.3 | HBsAg disappeared within 8 weeks after injection of 15 μg pAAV/HBV1.3; 60% mice were HBsAg-positive at week 20 after injection of 15 μg pcDNA3.1(+)-HBV1.3 |
| Li et al. ( 16 ) | C57BL/6 (male, 6-8 weeks) | 5, 10, or 100 μg pAAV/HBV1.2 | 80% mice were HBsAg positive for more than 6 months (5 μg); 40% mice were HBsAg positive for more than 6 months (10 μg); HBsAg was cleared at week 5 (100 μg); |
| BALB/c (male, 6-8 weeks) | 1 or 5 μg, pAAV/HBV1.2 | 20% HBsAg positive > 3 month (1μg); 60% HBsAg positive > 3 month (5 μg) | |
| Wang et al. ( 17 ) | C57BL/6 (male, 5-6 weeks) | 6 or 20 μg, pAAV/HBV1.2 | 100% HBsAg positive at 6 wpi (6 μg); HBsAg disappeared at 4 wpi (20 μg); |
| 6 μg pAAV/HBV1.2 + 14 μg pAAV/control | HBsAg disappeared at 4 wpi | ||
| Chou et al. ( 18 ) | BALB/cJ, FVB/NJ, NOD/ShiLtJ, 129×1/SvJ (male, 6 weeks) | 10 μg pAAV/HBV1.2 | HBsAg rapidly disappeared within 4 weeks after injection |
| C3H/HeN, C57BL/6, DBA/2J, CBA/caJ (male, 6 weeks) | 10 μg pAAV/HBV1.2 | 40% C57BL/6, 90% C3H/HeN, 75% DBA/2J, 100% CBA/caJ remained HBsAg-poitive at 8 wpi | |
| C3H/HeN, C57BL/6, DBA/2J, CBA/caJ (male, 12 weeks) | 10 μg pAAV/HBV1.2 | HBsAg disappeared at 5 wpi in C3H and DBA/2J mice; 12-week-old C57BL/6 mice accelerated HBsAg clearance compared to younger mice | |
| Peng et al. ( 19 ) | C3H/HeN (male, 5-6 weeks) | 10 μg pAAV/HBV1.2 | HBsAg persisted for up to 46 weeks |
| Yuan et al. ( 20 ) | AAVS1 (female and male, 6-8 weeks) | 10 μg pAAV/HBV1.2 | Male mice express higher levels of HBsAg, HBeAg than female mice |
| Kosinska et al. ( 15 ) | C57BL/6 (female and male, 9-10 weeks) | 10 μg pSM2 | Male mice express higher levels of HBsAg, HBeAg than female mice |
Dpi, days post injection; wpi, weeks post injection.