Table 2.
Serum HBsAg levels among different chronic HBV mouse model.
| Authors | Mouse background | Mouse model | HBsAg positive rate | HBsAg levels |
|---|---|---|---|---|
| Huang et al. ( 13 ) | C57BL/6 (male, 6-8 weeks) | HDI model 10 μg pAAV/HBV1.2 |
80% at 5 wpi | 10000 ng/ml at 1 wpi; 100-1000ng/ml at 5 wpi |
| Li et al. ( 14 ) | C57BL/6 (male, 6-8 weeks) | HDI model 15 μg pcDNA3.1(+)-HBV1.3 |
60% at 20 wpi | OD450: 3.0-3.5 at 1 wpi; ~1.5 at 20 wpi |
| Li et al. ( 16 ) | C57BL/6 (male, 6-8 weeks) | HDI model 5μg pAAV/HBV1.2 |
80% at 24 wpi | OD450: 2.5-3.0 at 1 wpi 1.0-2.5 at 24 wpi |
| Wang et al. ( 17 ) | C57BL/6 (male, 5-6 weeks) | HDI model 6 μg pAAV/HBV1.2, |
100% at 6 wpi | 1000 ng/ml at 1 wpi; 100-1000 ng/ml at 6 wpi |
| Peng et al. ( 19 ) | C3H/HeN (male, 5-6 weeks) | HDI model 10 μg pAAV/HBV1.2 |
90% at 46 wpi | 2000-3000 IU/ml at beginning; 60-100 IU/ml at 46 wpi |
| Huang et al. ( 46 ) | n.a | Ad-HBV vector Infected with 108 infectious unites of Ad-HBV |
n.a | 10000-100000 S/CO at 1 wpi; ~ 100 S/CO at day 100 after infection |
| Dion et al. ( 49 ) | HLA-A2/DR1 mice (male, 6-8 weeks) | AAV2/8-HBV vector Infected with 5×1010vg |
n.a | ~ 100 μg/ml at 2 wpi ~ 80 μg/ml at 16 wpi |
| Yang et al. ( 50 ) | C57BL/6 (male, 6-8 weeks) | AAV-HBV vector Infected with 1×1011vg |
n.a | 2000-3000 ng/ml at 2 wpi and 12 wpi |
| Yan et al. ( 60 ) | C3H (male, 4-6 weeks) | Rc-ccc DNA model HDI of 10 μg of HBVcircle |
100% at 7 wpi | 10000 ng/ml at 1 wpi; 1000-10000 ng/ml at 7 wpi |
HDI, hydrodynamic injection; HLA-A2/DR1, HLA-A*0201/DRB1*0101-transgenic, H-2 class I/class II knockout (KO) mice; n.a, not available; S/CO, signal to control ratio; wpi, weeks post injection.