Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 29;9:751892. doi: 10.3389/fcell.2021.751892

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Rehbein, Prentzell, Cadena Sandoval, Heberle, Henske, Opitz and Thedieck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

TSC complex-mTORC1 signaling during nutrient sufficiency and stress granule (SG) formation. The mechanisms are described in the text. AKT, AKT serine/threonine kinase; AKT1S1, AKT substrate 1; DYRK, dual specificity tyrosine phosphorylation regulated kinase 3; EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1; G3BP 1/2, stress granule assembly factor 1/2; HDLBP, high density lipoprotein binding protein; LAMP1/2, lysosomal associated membrane proteins 1/2; MTOR, mechanistic target of rapamycin kinase; PI3K, phosphoinositide 3-kinases; PI(3,5)P₂, phosphatidylinositol-3,5-bisphosphate; RHEB, RAS homolog-mTORC1 binding; RPS6KB1, ribosomal protein S6 kinase B1; RPTOR, regulatory associated protein of MTOR complex 1; SPAG5, sperm associated antigen 5; TSC1/2, TSC complex subunit 1/2; ULK1, unc-51 like autophagy activating kinase 1. Dashed arrow, inhibition via disassembly of mTORC1.