Table 2.
Noncoding RNAs in AD and Psoriasis.
| Noncoding RNAs | Targets/Regulators | Key Message | Disease | Ref. |
|---|---|---|---|---|
| miR-203 | SOC3; NR1H3/LXR-α; PRAR-ϒ | Regulate JAK2/STAT3 signaling pathway, by direct targeting SOC3; Modulated the proliferation of keratinocytes through direct targeting to LXR-α/PRAR-ϒ | Psoriasis; AD | (116–119) |
| miR-146a | CCL5; TRAF6; IRAK1; CARD10; COPS8 | Negatively regulated keratinocyte proliferation and inflammation pathways by targeting CCL5, TRAF6, IRAK1; Inhibits GRCR-mediated NF-ƘB activity by targeting CARD10 and COPS8 | Psoriasis | (120–122) |
| miR-155 | CTL4; PKIα; GATA3 | Associated in keratinocyte proliferation, inflammation and tight junction disruption; In T cells, it promotes T cell proliferation and TH17 responses by directly targeting CTL4; Regulate GATA3 and IL-37 mediated inflammatory responses in Psoriasis | AD; Psoriasis | (123–125) |
| miR-223 | PTEM | Positively correlation with Treg cell; Involved in AD through indirectly upregulating HMT to degrade excessive histamine in AD; Increase proliferation and inhibited apoptosis in IL-22 stimulated KCs | Psoriasis; AD | (126–129) |
| miR-143 | IL-13Rα1 | Decrease IL-13 activity and inflammatory responses via targeting IL-13Ra1 in AD; | Psoriasis; AD | (126, 127) |
| miR-369-3p | iNOS | miR-369-3p reduce NO production by targeting iNOS, and decreased the release of TNFα, IL-6, IL-12 et al. to regulate chronic inflammatory response | Psoriasis | (130, 131) |
| miR-151a | IL12RB2 | Negatively regulate IL-12 signaling | AD | (132, 133) |
| lncRNA-H19 | miR-130b-3p- Dsg1 axis | Regulate Dsg1 expression and consequently regulates keratinocyte differentiation through directly binds to miR-130b-3p | Psoriasis | (134, 135) |
| lncRNA-MSX2P1 | miR-6731-5p-S100A7 axis | Up-regulation of lncRNA-MSX2P1 promotes the IL-22-stimulated keratinocytes by inhibiting miR-6731-5p | Psoriasis | (136) |
| lncRNA-MEG3 | miR-21-caspase-8 axis | Down-regulated lncRNA MEG3 activates apoptosis though miR-21 suppressed caspase-8 | Psoriasis | (137) |
| lncRNA PRINS | G1P3 | Up-regulated lncRNA PRINS targets the anti-apoptotic G1P3 in keratinocytes, therefore diminish sensitivity of keratinocytes to spontaneous apoptosis through G1P3 | Psoriasis | (138) |
| IncRNA SPRR2C | miR-330-STAT1-S100A7 axis | Competed with STAT1 and S1000A7 to counteract miR-330-mediated suppression of STAT1 and S100A7 | Psoriasis | (139) |
| lncRNA MIR155HG | encode miPEP155 | Encode a micropeptide to regulate antigen presentation and suppress autoimmune inflammation | Psoriasis | (140) |