TABLE 2.
Validity metrics for the composite mortality variable across the 18 cancer types combined, overall, and stratified by sociodemographic and clinical characteristics
| Strata | N (%) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | 15‐day date Agreement, % (95% CI) | |
|---|---|---|---|---|---|---|---|
| Overall | Overall | 160 436 (100.0) | 89.2 (89.0, 89.4) | 97.4 (97.3, 97.5) | 97.8 (97.7, 97.9) | 87.5 (87.3, 87.7) | 97.0 (96.9, 97.2) |
| Practice type | Community | 145 212 (90.5) | 89.1 (88.9, 89.3) | 97.6 (97.5, 97.7) | 98.0 (97.9, 98.1) | 87.0 (86.8, 87.3) | 97.3 (97.2, 97.4) |
| Academic | 15 224 (9.5) | 91.0 (90.4, 91.6) | 95.3 (94.8, 95.8) | 95.0 (94.5, 95.5) | 91.5 (90.9, 92.1) | 94.6 (94.0, 95.1) | |
|
Age group a (at cohort entry) |
<35 | 1514 (0.9) | 86.9 (84.0, 89.7) | 98.5 (97.7, 99.2) | 96.9 (95.4, 98.4) | 93.1 (91.6, 94.6) | 96.3 (94.6, 98.0) |
| 35‐49 | 10 814 (6.7) | 88.3 (87.4, 89.2) | 97.9 (97.6, 98.3) | 97.1 (96.6, 97.6) | 91.5 (90.8, 92.1) | 96.5 (96.0, 97.1) | |
| 50‐64 | 50 435 (31.4) | 89.2 (88.8, 89.6) | 97.7 (97.5, 97.9) | 97.7 (97.5, 97.9) | 89.2 (88.9, 89.6) | 97.0 (96.8, 97.3) | |
| 65‐74 | 51 134 (31.9) | 89.3 (88.9, 89.6) | 97.4 (97.2, 97.7) | 97.9 (97.7, 98.0) | 87.4 (87.0, 87.8) | 97.1 (96.9, 97.3) | |
| 75+ | 46 538 (29.0) | 89.4 (89.1, 89.8) | 96.5 (96.2, 96.8) | 97.8 (97.7, 98.0) | 83.6 (83.1, 84.1) | 97.1 (96.9, 97.3) | |
| Race/ethnicity | White | 112 116 (69.9) | 91.4 (91.1, 91.6) | 98.0 (97.9, 98.1) | 98.4 (98.3, 98.5) | 89.6 (89.4, 89.9) | 97.8 (97.6, 97.9) |
| Afr.American | 13 111 (8.2) | 88.0 (87.2, 88.7) | 98.0 (97.6, 98.3) | 98.2 (97.9, 98.5) | 86.5 (85.7, 87.3) | 97.3 (96.9, 97.7) | |
| Hisp/Latino | 433 (0.3) | 84.4 (79.8, 88.9) | 91.6 (87.6, 95.5) | 92.8 (89.3, 96.2) | 82.1 (76.9, 87.2) | 92.3 (88.8, 95.8) | |
| Asian | 3270 (2.0) | 76.3 (74.2, 78.4) | 95.1 (94.0, 96.1) | 93.6 (92.2, 94.9) | 81.0 (79.3, 82.7) | 92.7 (91.3, 94.1) | |
| Other/missing | 31 506 (19.6) | 83.4 (82.8, 83.9) | 95.2 (94.9, 95.6) | 95.7 (95.4, 96.0) | 81.7 (81.1, 82.3) | 94.6 (94.3, 95.0) | |
| Region | Midwest | 22 339 (13.9) | 94.1 (93.7, 94.5) | 98.0 (97.7, 98.3) | 98.5 (98.3, 98.7) | 92.3 (91.8, 92.8) | 97.7 (97.4, 98.0) |
| Northeast | 40 799 (25.4) | 91.5 (91.1, 91.8) | 97.2 (96.9, 97.4) | 97.6 (97.4, 97.8) | 89.9 (89.4, 90.3) | 97.1 (96.8, 97.3) | |
| South | 63 896 (39.8) | 90.9 (90.6, 91.2) | 97.7 (97.6, 97.9) | 98.2 (98.0, 98.3) | 88.8 (88.5, 89.2) | 97.5 (97.3, 97.7) | |
| West | 30 599 (19.1) | 82.4 (81.8, 83.0) | 96.6 (96.3, 96.9) | 96.6 (96.3, 96.9) | 82.6 (82.0, 83.1) | 95.6 (95.3, 96.0) | |
| Other/missing | 2803 (1.7) | 46.8 (44.3, 49.4) | 95.8 (94.8, 96.9) | 92.4 (90.5, 94.3) | 62.4 (60.3, 64.5) | 90.5 (88.4, 92.6) | |
| Lines of therapy | Not documented | 44 911 (28.0) | 85.6 (85.1, 86.0) | 97.1 (96.8, 97.3) | 97.4 (97.1, 97.6) | 84.3 (83.8, 84.7) | 96.6 (96.3, 96.8) |
| <3 L | 92 531 (57.7) | 90.0 (89.7, 90.3) | 97.5 (97.4, 97.7) | 97.8 (97.7, 97.9) | 88.8 (88.6, 89.1) | 97.0 (96.9, 97.2) | |
| 3 L+ | 22 994 (14.3) | 92.9 (92.5, 93.3) | 97.3 (96.9, 97.6) | 98.3 (98.1, 98.5) | 88.9 (88.2, 89.5) | 97.8 (97.5, 98.0) | |
| <4 L | 104 947 (65.4) | 90.2 (90.0, 90.5) | 97.5 (97.4, 97.6) | 97.9 (97.7, 98.0) | 88.7 (88.5, 89.0) | 97.1 (97.0, 97.3) | |
| 4 L+ | 10 578 (6.6) | 94.1 (93.6, 94.7) | 97.3 (96.8, 97.8) | 98.4 (98.1, 98.7) | 90.3 (89.4, 91.2) | 97.9 (97.5, 98.2) | |
| <5 L | 110 593 (68.9) | 90.4 (90.2, 90.7) | 97.5 (97.3, 97.6) | 97.9 (97.8, 98.0) | 88.8 (88.5, 89.0) | 97.2 (97.0, 97.3) | |
| 5 L+ | 4932 (3.1) | 94.5 (93.7, 95.3) | 97.9 (97.2, 98.6) | 98.7 (98.3, 99.1) | 91.1 (89.8, 92.4) | 98.2 (97.8, 98.7) |
Abbreviations: L, line of therapy; NPV, negative predictive value; PPV, positive predictive value.
a
One patient had unknown age and was not analyzed for stratification by age group.