Figure 1.

Schematic of the function of γδ T cells. γδ T cells can be activated by stress signals from infected or tumour cells. Stressed or infected cells can express MICA and MICB which γδ T cells can recognise via the NKG2D receptor. Furthermore, the overexpression of certain molecules such as IPP can be recognised through the γδ TCR by recognising BTN3A and BTN2A on stressed or infected cells. γδ T cells can respond via different channels. This can be the production of cytokines (IFN-γ, TNF-α, IL-6, IL-17) or cytolysis (Perforin, Granzyme). Additionally, γδ T cells can interact with other immune cells and present antigens. Created by BioRender.