Table 2.
Most enriched GO terms: molecular function, biological process, cellular component.
| Molecular Function | Name | pValue | Bonferroni | Genes from Input | Genes in Annotation |
|---|---|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | 7.382E-85 | 3.071E-82 | 62 | 185 |
| GO:0005198 | structural molecule activity | 4.696E-46 | 1.954E-43 | 63 | 743 |
| GO:0005518 | collagen binding | 8.911E-31 | 3.707E-28 | 24 | 82 |
| GO:0005539 | glycosaminoglycan binding | 8.596E-26 | 3.576E-23 | 30 | 252 |
| GO:0005102 | signaling receptor binding | 5.808E-24 | 2.416E-21 | 64 | 1842 |
| GO:0002020 | protease binding | 1.035E-22 | 4.306E-20 | 31 | 350 |
| GO:0008233 | peptidase activity | 2.736E-22 | 1.138E-19 | 44 | 868 |
| GO:0005178 | integrin binding | 4.904E-22 | 2.040E-19 | 23 | 157 |
| GO:0019838 | growth factor binding | 2.418E-21 | 1.006E-18 | 23 | 168 |
| GO:0004175 | endopeptidase activity | 1.300E-20 | 5.407E-18 | 37 | 640 |
| Biological Process | Name | pValue | Bonferroni | Genes from Input | Genes in Annotation |
| GO:0030198 | extracellular matrix organization | 3.792E-82 | 1.601E-78 | 76 | 431 |
| GO:0043062 | extracellular structure organization | 4.581E-82 | 1.934E-78 | 76 | 432 |
| GO:0045229 | external encapsulating structure organization | 6.673E-82 | 2.818E-78 | 76 | 434 |
| GO:0022610 | biological adhesion | 1.685E-42 | 7.115E-39 | 79 | 1578 |
| GO:0007155 | cell adhesion | 1.314E-41 | 5.549E-38 | 78 | 1571 |
| GO:0030199 | collagen fibril organization | 3.530E-38 | 1.491E-34 | 26 | 63 |
| GO:0001944 | vasculature development | 1.370E-27 | 5.785E-24 | 50 | 903 |
| GO:0001568 | blood vessel development | 1.871E-26 | 7.900E-23 | 48 | 866 |
| GO:0001501 | skeletal system development | 1.963E-26 | 8.288E-23 | 41 | 583 |
| GO:0016477 | cell migration | 8.552E-25 | 3.611E-21 | 64 | 1812 |
| Cellular Component | Name | pValue | Bonferroni | Genes from Input | Genes in Annotation |
| GO:0031012 | extracellular matrix | 5.96E-148 | 2.14E-145 | 122 | 633 |
| GO:0030312 | external encapsulating structure | 9.09E-148 | 3.27E-145 | 122 | 635 |
| GO:0062023 | collagen-containing extracellular matrix | 1.505E-147 | 5.41E-145 | 115 | 498 |
| GO:0005788 | endoplasmic reticulum lumen | 3.938E-54 | 1.418E-51 | 53 | 323 |
| GO:0005604 | basement membrane | 9.433E-38 | 3.396E-35 | 31 | 122 |
| GO:0005581 | collagen trimer | 2.900E-25 | 1.044E-22 | 21 | 87 |
| GO:0034774 | secretory granule lumen | 7.695E-23 | 2.770E-20 | 30 | 324 |
| GO:0060205 | cytoplasmic vesicle lumen | 1.101E-22 | 3.965E-20 | 30 | 328 |
| GO:0031983 | vesicle lumen | 1.315E-22 | 4.734E-20 | 30 | 330 |
| GO:0031091 | platelet alpha granule | 1.522E-21 | 5.481E-19 | 19 | 92 |
Selection based on p-value and adjusted with Bonferroni correction. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO terms. The full output table generated by ToppFun is shown in Supplementary Table S4.