Table 7.
Most enriched GO terms: Molecular function, classed by fold increase.
| GO molecular function | Hit count in query list | Hit count in the genome | Hit in query list | Fold | P value |
|---|---|---|---|---|---|
| extracellular matrix structural constituent conferring compression resistance GO:0030021 | 4 | 22 | HSPG2, HAPLN1, LUM, DCN. | >100 | 2.32E-4 |
| extracellular matrix structural constituent conferring tensile strength GO:0030020 | 4 | 41 | COL6A3, COL6A2, COL14A1, COL8A1. | 60.89 | 2.27E-3 |
| collagen binding GO:0005518 | 6 | 70 | COL14A1, LUM, COL6A2, DCN, NID2, FN1 | 53.49 | 6.15E-6 |
| extracellular matrix structural constituent GO:0005201 | 14 | 173 | HSPG2, THBS2, SRPX, HAPLN1, COL8A1, COL6A2, COL6A3, LUM, COL14A1, EDIL3, IGFBP7, NID2, DCN, FN1. | 50.50 | 3.20E-17 |
| integrin binding GO:0005178 | 6 | 147 | HSPG2, TIMP2, PTN, FAP, EDIL3, FN1. | 25.47 | 4.16E-4 |
| glycosaminoglycan binding GO:0005539 | 6 | 234 | THBS2, HAPLN1, PTN, DCN, FN1, CEMIP. | 16.00 | 5.83E-3 |
Selection based on p-value and adjusted with Bonferroni correction. Hit count in genome shows the number of genes in a given pathway, and the hit count in query list shows how many genes in the query list are hit in a given GO term. The full output table generated by ToppFun is shown in Supplementary Table S7.