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. 2021 Oct 29;12:752940. doi: 10.3389/fphys.2021.752940

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Copyright © 2021 Cooper, Gloschat, Swift, Prudencio, McCullough, Jaimes and Posnack.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myocardial injury via radiofrequency ablation diminishes electrical and calcium signals. (A) Langendorff-perfused rat heart after radiofrequency ablation showing two regions of interest and corresponding traces. The voltage signal (red) and calcium signal (blue) are collected from the ablation site (denoted with dotted line) and non-ablated tissue. (B) Voltage and calcium isochronal maps display activation time across the heart, with disruption at the site of ablation injury. Epicardial dynamic pacing from the apex of the heart.