Table 1.
Comparison between patients with low (lower median value) vs. high (higher median value) of LPS at T1 (baseline) (n = 187).
| Variable [median (IQR) or n (%)] | Low LPS (<37.7) (n = 93) | High LPS (>37.7) (n = 94) | P-value |
|---|---|---|---|
| PMX-HP | 45 (48.4) | 49 (52.1) | 0.61 |
| Age | 72 [63; 78] | 73 [64; 79] | 0.54 |
| Sex (male) | 53 (57) | 50 (53.2) | 0.60 |
| SAPS II | 56 [48; 66] | 61 [49; 69] | 0.14 |
| SOFA* at day 0 | 8 [6; 9] | 8 [7; 10] | 0.12 |
| SOFA* at day 3 (miss = 11) | 7 [6; 9] | 8 [5; 10] | 0.68 |
| Source of the infection | |||
| Undetermined | 15 (16.1) | 11 (11.7) | <0.01 |
| Biliary peritonitis | 1 (1.1) | 13 (13.8) | |
| Lower GI perforation | 63 (67.7) | 43 (45.7) | |
| Upper GI perforation | 14 (15.1) | 27 (28.7) | |
| Nosocomial | 56 (60.2) | 50 (53.2) | 0.33 |
| Treatments characteristics | |||
| Adequate antibiotic therapy (miss = 2) | 75 (81.5) | 76 (81.7) | 0.93 |
| Microbiological findings | |||
| Gram negative bacteria | 64 (68.8) | 58 (61.7) | 0.31 |
| Gram positive bacteria | 44 (47.3) | 47 (50) | 0.71 |
| Fungi | 16 (17.2) | 12 (12.8) | 0.40 |
| No isolation | 8 (8.6) | 11 (11.7) | 0.48 |
| Outcomes | |||
| Mortality at day 28 | 13 (14) | 28 (29.8) | <0.01 |
| Mortality at day 90 | 16 (17.2) | 36 (38.3) | <0.01 |
| Biomarkers | |||
| LPS (pmole/ml) | 28.1 [22.7; 33] | 52.5 [44.3; 70] | <0.01 |
| PLTP T1 | 431.1 [307.9; 589.4] | 487.6 [408; 643.8] | <0.01 |
| Ratio LPS to PLTPT1 (%) | 6.2 [4.8; 8.9] | 11.5 [8.6; 15.1] | <0.01 |
| Cholesterol T1 | 0.4 [0.3; 0.6] | 0.5 [0.4; 0.7] | 0.02 |
| HDL T1 | 0.1 [0; 0.1] | 0.1 [0; 0.2] | 1.00 |
| LDL T1 | 0.1 [0; 0.1] | 0.1 [0; 0.1] | 0.99 |
| TG T1 | 0.6 [0.4; 1.1] | 0.7 [0.5; 1.2] | 0.14 |
| IL10 T1 (miss = 8) | 205.9 [69.5; 865.5] | 211.5 [87.2; 557.6] | 0.59 |
| IL6 T1 (miss = 8) | 2102.3 [557.2; 9212.1] | 1583.2 [388.2; 8264.9] | 0.35 |
| Delta (T4–T1) LPS (miss = 22) | 14.1 [4.6; 23.7] | 1.5 [−9.8; 26] | <0.01 |
| Delta (T4–T1) IL10 (miss = 24) | −75.2 [−327.9; −10.9] | −68 [−266.8; −0.9] | 0.21 |
| Delta (T4–T1) IL6 (miss = 24) | −1414.7 [−4332.7; −358.4] | −509.4 [−3681.1; −72.7] | 0.01 |
IQR, Interquartile range; SAPS, simplified acute physiologic score; PMX-HP, Polymyxin-B hemoperfusion; T1, baseline; PLTP, Phospholipid transfer protein; IL, Interleukin; Delta, variations from baseline (T1) to (T4) (T4-T1).
*
SOFA score excluding the neurological alteration.