Table 2.
Comparison between the groups of patients alive or dead at day 28 (n = 187).
| Variable (median [IQR) or n (%)] | Alive at day 28 (n = 147) | Dead at day 28 (n = 41) | P-value |
|---|---|---|---|
| PMX-HP | 71 (48.3) | 23 (56.1) | 0.38 |
| Age | 71 [61; 78] | 77 [67; 79] | <0.01 |
| Sex (male) | 83 (56.5) | 21 (51.2) | 0.55 |
| SAPS II | 56 [48; 64] | 67 [61; 79] | <0.01 |
| SOFA* at day 0 | 8 [6; 9] | 9 [7; 10] | 0.08 |
| SOFA* at day 3 (miss = 11) | 7 [5; 9] | 9 [7; 10] | 0.01 |
| Source of the infection | |||
| Undetermined | 21 (14.3) | 5 (12.2) | 0.26 |
| Biliary peritonitis | 8 (5.4) | 6 (14.6) | |
| Lower GI perforation | 86 (58.5) | 21 (51.2) | |
| Upper GI perforation | 32 (21.8) | 9 (22) | |
| Nosocomial | 81 (55.1) | 26 (63.4) | 0.34 |
| Treatments characteristics | |||
| Adequate antibiotic therapy (miss = 2) | 116 (80) | 35 (85.4) | 0.46 |
| Microbiological findings | |||
| Gram negative bacteria | 93 (63.3) | 29 (70.7) | 0.38 |
| Gram positive bacteria | 68 (46.3) | 23 (56.1) | 0.26 |
| Fungi | 21 (14.3) | 7 (17.1) | 0.66 |
| No isolation | 16 (10.9) | 3 (7.3) | 0.50 |
| Biomarkers | |||
| LPS (pmole/ml) T1 (miss = 1) | 36.5 [27; 48.1] | 45.5 [35.1; 63.1] | 0.02 |
| PLTP T1 (miss = 1) | 469.8 [366.7; 587.9] | 437.8 [327.5; 715.9] | 0.88 |
| Ratio LPS to PLTP T1 (%) (miss = 1) | 8.4 [5.8; 11.5] | 10.1 [7; 14] | 0.03 |
| Cholesterol T1 (miss = 1) | 0.5 [0.3; 0.6] | 0.4 [0.3; 0.6] | 0.18 |
| HDL T1 (miss = 1) | 0.1 [0; 0.2] | 0.1 [0; 0.1] | 0.91 |
| LDL T1 (miss = 1) | 0.1 [0; 0.1] | 0.1 [0; 0.1] | 0.40 |
| TG T1 (miss = 1) | 0.7 [0.5; 1.2] | 0.7 [0.5; 0.9] | 0.58 |
| Protein T1 (miss = 1) | 33.9 [29.6; 38.8] | 32.6 [27.2; 36.3] | 0.10 |
| IL-10 T1 (miss = 9) | 170 [69.6; 453.9] | 432.5 [134.2; 1,247.6] | 0.01 |
| IL-6 T1 (miss = 9) | 1524.9 [474.5; 7796.8] | 7134.4 [1,083.6; 14190.1] | <0.01 |
| Delta (T4-T1) LPS (miss = 23) | 7.8 [−2.7; 21.2] | 24.6 [−5.5; 51] | 0.03 |
| Delta (T4-T1) PLTP (miss = 24) | 151.8 [58.1; 325] | 117.2 [31.5; 258.1] | 0.28 |
| Delta (T4-T1) IL10 (miss = 25) | −82.3 [−319.5; −11.5] | −19.6 [−168.5; 90.3] | 0.02 |
| Delta (T4-T1) IL6 (miss = 25) | −862.8 [−4038.7; −235.9] | −840.7 [−5458.9; 0] | 0.51 |
IQR, Interquartile range; SAPS, simplified acute physiologic score; PMX-HP, Polymyxin-B hemoperfusion; T1, baseline; PLTP, Phospholipid transfer protein; IL, Interleukin; Delta, variations from baseline (T1) to (T4) (T4-T1).
*
SOFA score excluding the neurological alteration.