Table 3.
Comparison between the patients having a low (infra median) vs. high (supra median) level of PLTP on the whole cohort (n = 187).
| Variable | Low PLTP (n = 93) | High PLTP (n = 94) | P-value |
|---|---|---|---|
| PMX-HP | 45 (48.4) | 49 (52.1) | 0.61 |
| Age | 71 [64; 78] | 73 [63; 79] | 0.26 |
| Sex, male | 58 (62.4) | 45 (47.9) | 0.05 |
| SAPS II | 57 [48; 67] | 58 [50; 67] | 0.60 |
| SOFAa at day 0 | 8 [6; 9] | 8 [7; 10] | 0.24 |
| SOFAa at day 3 (missing = 11) | 7 [6; 9] | 7 [5; 9] | 0.72 |
| Source of the infection | |||
| Undetermined | 13 (14) | 13 (13.8) | 0.09 |
| Biliary peritonitis | 4 (4.3) | 10 (10.6) | |
| Lower GI perforation | 60 (64.5) | 46 (48.9) | |
| Upper GI perforation | 16 (17.2) | 25 (26.6) | |
| Nosocomial | 51 (54.8) | 55 (58.5) | 0.61 |
| Treatment characteristics | |||
| Adequate antibiotic therapy (missing = 2) | 74 (81.3) | 77 (81.9) | 0.54 |
| Microbiological findings | |||
| Gram-negative bacteria | 58 (62.4) | 64 (68.1) | 0.41 |
| Gram-positive bacteria | 44 (47.3) | 47 (50) | 0.71 |
| Fungi | 13 (14) | 15 (16) | 0.70 |
| No isolation | 12 (12.9) | 7 (7.4) | 0.22 |
| Outcomes | |||
| Mortality at day 28 | 23 (24.7) | 18 (19.1) | 0.36 |
| Mortality at day 90 | 27 (29) | 25 (26.6) | 0.71 |
| Biomarkers | |||
| LPS T1, pmole/ml | 36.1 [26.2; 46.9] | 43.6 [29.5; 56.4] | 0.01 |
| PLTP T1 | 357.9 [283.3; 414.2] | 600.8 [520.1; 731.7] | <0.01 |
| LPS:PLTP ratio T1, % | 10.5 [8.2; 14] | 6.8 [4.9; 9.6] | <0.01 |
| Cholesterol T1 | 0.4 [0.3; 0.5] | 0.6 [0.4; 0.7] | <0.01 |
| HDL T1 | 0.1 [0; 0.2] | 0.1 [0; 0.1] | 0.87 |
| LDL T1 | 0.1 [0; 0.1] | 0.1 [0; 0.1] | 0.86 |
| TG T1 | 0.6 [0.4; 0.9] | 0.8 [0.5; 1.2] | <0.01 |
| Proteins T1 | 32.5 [26; 37.8] | 34.3 [30.5; 38.8] | 0.04 |
| IL-10 T1 (missing = 8) | 263.3 [77.2; 979.5] | 179.1 [76.4; 414.8] | 0.16 |
| IL-6 T1 (missing = 8) | 3807.1 [692.7; 10,315.9] | 1195 [429; 6504.1] | <0.01 |
| Delta LPS (missing = 22) | 10 [1; 24.6] | 9.9 [−4.8; 21.5] | 0.42 |
| Delta PLTP (missing = 23) | 208.5 [101.6; 362.6] | 91.5 [−13.4; 232.4] | <0.01 |
| Delta LPS/PLTP ratio, % (missing = 24) | −2.5 [−4.4; 1] | 0.2 [−1.7; 2.5] | <0.01 |
| Delta IL-10 (missing = 24) | −82.3 [−413.1; −10.5] | −69.1 [−270.1; −1.8] | 0.34 |
| Delta IL-6 (missing = 24) | −1409.5 [−5951.2; −293.8] | −733 [−3653.8; −123.2] | 0.06 |
Data are presented as median (interquartile range) or n (%).
SAPS, Simplified Acute Physiological Score; PMX-HP, polymyxin-B hemoperfusion; T1, baseline; PLTP, phospholipid transfer protein; IL, interleukin; Delta, variations from baseline (T1) to (T4) (T4-T1).
a
SOFA score excluding the neurological alteration.