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. 2021 Oct 29;12:697622. doi: 10.3389/fimmu.2021.697622

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Copyright © 2021 Tang, Huang, Luo, Liu, Lin, Mao, Wu, Xiong, Hou, Sun and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic analysis of routine blood test and cytokines in patients with different outcomes. (A) The absolute numbers of neutrophils, lymphocytes, platelets, and NLR and (B) the values of IL-2R, IL-6, IL-10, and IL-2R/lymphocytes in the peripheral blood of mild (yellow line), severe (blue line), and deceased (red line) COVID-19 patients were analyzed at different time points (every 3 days from day 3 to day 45 after onset of illness). Data in each time point are expressed as median with interquartile range. The smoothing cubic splines were fitted to the values of different parameters to summarize the overall trend. NLR, neutrophil-to-lymphocyte ratio; IL-2R, IL-2 receptor. ^ap < 0.05; ^bp < 0.01; ^cp < 0.001. M, mild; S, severe; D, deceased.