FIGURE 2.

Anti–tumor effects of temozolomide (TMZ), lomustine (CCNU), and nimustine (ACNU) against the glioblastoma (GBM) cell clones with acquired TMZ resistance and their parental GBM cells. A, The indicated GBM cells were treated with vehicle (DMSO), 200 μM of TMZ, CCNU, or ACNU. After 96 h, the mortality rates of these cells were determined by dye exclusion assay. B, The indicated GBM cells were treated with vehicle (DMSO) and TMZ, CCNU, or ACNU as indicated. After 96 h, the mortality rates of these cells were determined by dye exclusion assay. ^* P <.05, ^** P <.01