TABLE 5.

Pharmacokinetic parameters of DHC.

Pharmacokinetic parameters	DHC A	DHC B	DHC C
Cmax (μg·mL−1)	6.1 ± 3.2	7.5 ± 1.1	9.2 ± 2.4*
Tmax (min)	26.0 ± 5.5	22.0 ± 4.5	18.0 ± 2.7*
T1/2 (min)	24.8 ± 9.3	25.4 ± 6.3	114.3 ± 31.2*
AUC(0-tn) (μg·min·mL−1)	456.6 ± 54.6	423.4 ± 25.8	1,006.0 ± 63.8*
Vd (mL)	9,087.6 ± 302.9	2,802.6 ± 133.4*	3,751.4 ± 165.6*
CL (mL·min−1)	233.2 ± 7.8	70.0 ± 3.3*	52.7 ± 2.3*

*The results of variance analysis with A showed a significant difference (p < 0.05).

Group of A: Group of CUR.

Group of B: Group of CUR and PIP.

Group of C: Group of CUR and ILE.