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Drug concentrations of plasma and brain after multiple doses.
| Compounds | Mean concentrations±sd (μg·mL−1) | CV (%) | |
| Plasma | DHCI | 1.4 ± 0.6 | 42.8 |
| DHCII * | 4.6 ± 1.8 | 39.1 | |
| PIP | 2.4 ± 0.5 | 20.8 | |
| DHCIII * | 8.7 ± 2.5 | 28.7 | |
| ILE | 2.8 ± 0.3 | 10.7 | |
| Brain | CUR | ND | — |
| DHC | ND | — | |
| PIP | 2.1 ± 0.1 | 4.8 | |
| ILE | 1.6 ± 0.2 | 12.5 | |
*The results of variance analysis with A showed a significant difference (p < 0.05).
Group of I: Group of CUR.
Group of II: Group of CUR and PIP.
Group of III: Group of CUR and ILE.
