TABLE 1.

Virus-host interactome: mechanisms of EC senescence.

Viral antigen	Human Protein	EC senescence mechanism	References
S2	Furin/plasmin	BDNF dysfunction	Gray and Ellis (2008); Gordon et al. (2020)
S1	ACE-2	Mitochondrial dysfunction	Gordon et al. (2020); Paris et al. (2020)
NSP6	Sigma-1	BDNF, Mitochondrial dysfunction	Hashimoto (2015); Gordon et al. (2020)
ORF9b	TOM70	Mitochondrial dysfunction	Gordon et al. (2020)
E	BRD2/BRD4	Mitochondrial dysfunction	Gordon et al. (2020); Johnson et al. (2020)