Fig. 6.

Uptake of RBCEVs by endothelial cells in Apoe^−/− mice. (a) Schematic of Apoe^−/- mice. (b) Small animal optical imaging system. (c) Quantitative analysis of (b). (d) Oil Red O Staining on the total aorta. (e) to (g) Laser confocal images in the aorta. The white box indicates that the picture is locally enlarged, as indicated by the white arrow. (h) Quantitative analysis of mean fluorescence intensity and (i) uptake ratio. L: lumen. (n = 8) (scale bar = 20 μm) (scale bar = 5 μm). Significance is indicated as no significance (ns), or P < 0.001 (***).