Table 4.
Secondary outcomes for skin preparation type by treatment group and wound classification stratum, in randomised patients who had abdominal surgery
|
Clean-contaminated stratum (n=3051) |
Contaminated or dirty stratum (n=2662) |
|||||
|---|---|---|---|---|---|---|
| Chlorhexidine (n=1521) | Povidone–iodine (n=1530) | Treatment effect (RR, 95% CI) | Chlorhexidine (n=1337) | Povidone–iodine (n=1325) | Treatment effect (RR, 95% CI) | |
| SSI at discharge | ||||||
| Yes | 93 (6·4%) | 94 (6·4%) | 0·99 (0·76–1·30) | 229 (19·7%) | 247 (21·4%) | 0·93 (0·80–1·08) |
| No | 1367 (93·6%) | 1384 (93·6%) | .. | 936 (80·3%) | 905 (78·6%) | .. |
| Missing | 61 | 52 | .. | 172 | 173 | .. |
| Reoperation for SSI within 30 days of surgery | ||||||
| Yes | 10 (0·7%) | 6 (0·4%) | 1·58 (0·58–4·28)* | 38 (3·2%) | 38 (3·3%) | 0·97 (0·63–1·49) |
| No | 1441 (99·3%) | 1459 (99·6%) | .. | 1143 (96·8%) | 1118 (96·7%) | .. |
| Missing | 70 | 65 | .. | 156 | 169 | .. |
| Mortality within 30 days of surgery | ||||||
| Yes | 40 (2·7%) | 28 (1·9%) | 1·44 (0·90–2·31) | 121 (9·3%) | 119 (9·3%) | 1·00 (0·79–1·27) |
| No | 1449 (97·3%) | 1467 (98·1%) | .. | 1178 (90·7%) | 1155 (90·7%) | .. |
| Missing | 32 | 35 | .. | 38 | 51 | .. |
| Unplanned wound opening within 30 days of surgery | ||||||
| Yes | 211 (14·5%) | 216 (14·7%) | 0·98 (0·84–1·15) | 261 (21·9%) | 288 (24·7%) | 0·90 (0·79–1·03) |
| No | 1246 (85·5%) | 1252 (85·3%) | .. | 929 (78·1%) | 876 (75·8%) | .. |
| Missing | 64 | 62 | .. | 147 | 161 | .. |
| Length of hospital stay for index admission (days) | ||||||
| Median (IQR) | 5·0 (4·0–8·0) | 5·0 (4·0–8·0) | 1·01 (0·94–1·09)† | 8·0 (5·0–12·0) | 8·0 (5·0–13·0) | 1·08 (1·00–1·18)† |
| Missing | 64 | 51 | .. | 172 | 174 | .. |
| Readmission within 30 days of surgery | ||||||
| Yes | 29 (2·0%) | 40 (2·7%) | 0·72 (0·45–1·15) | 53 (4·5%) | 60 (5·2%) | 0·88 (0·62–1·26) |
| No | 1423 (98·0%) | 1427 (97·3%) | .. | 1129 (95·5%) | 1098 (94·8%) | .. |
| Missing | 64 | 52 | .. | 155 | 167 | .. |
| Return to normal activities within 30 days of surgery | ||||||
| Yes‡ | 594 (40·9%) | 597 (40·7%) | 1·01 (0·94–1·07) | 364 (30·8%) | 349 (30·2%) | 1·00 (0·91–1·10) |
| No | 859 (59·1%) | 870 (59·3%) | .. | 818 (69·2%) | 808 (69·8%) | .. |
| Missing | 68 | 63 | .. | 155 | 168 | .. |
Data are number (%), unless otherwise indicated. Percentages presented ignore any missing data. RR=relative risk. SSI=surgical site infection.
*
Age removed from model as model did not converge due to multicollinearity.
†
Data are hazard ratio (95% CI).
‡
Yes=completely returned to normal activities.