REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-mouse influenza B HA	Sino Biological Inc.	11053-RP01
HRP-conjugated anti-mouse IgG1, IgG2a, IgG2b	Jackson Immunoresearch Laboratories	115-035-205, 115-035-206, 115-035-207
HRP-conjugated anti-mouse IgG	Cytiva Lifescience	NA9311ML
anti-mouse IgA	Life Technologies	LS626720
Tetramethylbenzidine (TMB) substrate	Cell Signaling Technology	7004
Rabbit polyclonal anti-influenza B NP	Genetex	GTX128538
HRP-conjugated anti-rabbit IgG antibody	Cytiva	NA9341ML
Fixable Viability Dye eFluor 506	eBioscience	65-0866-14
anti-mouse CD16/CD32	eBioscience	16-0161-86
AF647-conjugated anti-mouse Ly77/GL7 (clone GL7)	BD Biosciences	561529
PE-Cy7-conjugated anti-mouse CD45R/B220 (clone RA3-6B2)	BD Biosciences	552772
Bacterial and virus strains
B/Victoria/2/87,	Icahn School of Medicine at Mount Sinai (Ermler et al., 2017	N/A
B/Yamagata/16/88	Icahn School of Medicine at Mount Sinai (Ermler et al., 2017	N/A
B/Brisbane/60/08	Icahn School of Medicine at Mount Sinai (Ermler et al., 2017	N/A
mouse-adapted B/Florida/4/06	Icahn School of Medicine at Mount Sinai (Ermler et al., 2017	N/A
Biological samples
Tissue samples from DBA/2J mice used in this study; the animals were purchased from Jackson lab	This study	N/A
Chemicals, peptides, and recombinant proteins
FFGAIAGFL	New England Peptides	P1
YYSTAASSL	New England Peptides	P2
DRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTP TKSYFANLKGTRTRGKLC	New England Peptides	HA1 linker (N-term
EADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVK TPLKLANGTKYRPPAKLLKER	New England Peptides	HA1 linker (C-term
B/Florida/4/06 HA2 protein	Sinobiologcals	Cat: 11053-V01H2
Critical commercial assays
Promega ADCC Reporter Bioassay	Promega	M1212
Bio-GloTM luciferase assay	Promega	G7941
Adeno-X Rapid Titer Kit	Takara Bio USA Inc	632250
Gateway®-adapted ViraPowerTM adenoviral expression system	Life Technologies	V49320
ProcartaPlex Multiplex Immunoassay kit	Life Technologies	EPX170-26087-901
Deposited data
Division of Regulatory Research (CG-IBV data)	Health Canada, Ottawa, Canada	N/A
Experimental models: Cell lines
FcγRIV effector cell	Promega	M1212
MDCK	ATCC	CCL-34
HeLa	ATCC	CCL-2
HEK293A	Qbiogene	AES2044
Experimental models: Organisms/strains
DBA/2J mice	(The Jackson Laboratory)	000671
Recombinant DNA
pBluescript II SK+ vector	Bio Basic Canada Inc.	N/A
pENTRTM/SD/D-TOPO vector	Life Technologies	K242020
pAd/CMV/V5-DEST vector	Life Technologies	V493-20
Software and algorithms
Geneious Prime	Geneious.	Geneious Prime
GraphPad Prism 8	GraphPad Software Inc.	GraphPad Prism 8
BD FACSDIVA 6.2	BD Biosciences	BD FACSDIVA 6.2
MILLIPLEX Analyst version 5.1	Merck Millipore	MILLIPLEX Analyst version 5.1
Original Code for Bioinformatics Analysis	Zenodo	https://doi.org/10.5281/zenodo.5573271 (https://zenodo.org/record/5573271)