1.

RA-凋亡-焦亡相关靶蛋白网络的拓扑参数

Topological parameters of the RA-apoptosis-pyroptosis-related target protein network

Number	Gene	Protein name	Uniprot ID	Betweenness Centrality	Degree
1	TNF	Tumor necrosis factor	P01375	0.06515	23
2	IL6	Interleukin 6	P05231	0.10051	23
3	IL1B	Interleukin-1 beta	P01584	0.07214	22
4	CASP1	Caspase-1	P29466	0.09480	21
5	CXCL8	Interleukin-8	P10145	0.03019	19
6	STAT1	Signal transducer and activator of transcription 1	P42224	0.05663	19
7	JUN	Transcription factor AP-1	P05412	0.05383	19
8	CCL2	C-C motif chemokine 2	P13500	0.02134	17
9	IL18	Interleukin-18 receptor accessory protein	O95256	0.02507	16
10	TRAF6	TNF receptor-associated factor 6	Q9Y4K3	0.01085	15
11	TNFAIP3	Yumor necrosis factor alpha-induced protein 3	P21580	0.01046	14
12	FAS	Tumor necrosis factor receptor superfamily member 6	P25445	0.00450	13
13	F ASLG	Tumor necrosis factor ligand superfamily member 6	P48023	0.00416	12
14	IFNB1	Interferon beta	P01574	0.00392	12
15	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	Q13546	0.00321	11
16	CTSB	Cathepsin B	P07858	0.02144	11
17	CXCL2	C-X-C motif chemokine 2	P19875	0.00054	11
18	BCL2A1	Bcl-2-related protein A1	Q16548	0.00343	10
19	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	0.00215	10
20	TRAF1	TNF receptor-associated factor 1	Q13077	0.00141	9
21	CTSL	Procathepsin L	P07711	0.01029	8
22	CTSK	Cathepsin K	P43235	0.01108	8
23	P2RX7	P2X purinoceptor 7	Q99572	0.00000	7
24	TYK2	Non-receptor tyrosine-protein kinase TYK2	P29597	0.00026	6
25	CTSD	Cathepsin D	P07339	0.00311	5
26	CTSS	Cathepsin S	P25774	0.00206	4
27	TXNIP	Thioredoxin-interacting protein	Q9H3M7	0.00000	3
28	MAPK12	Mitogen-activated protein kinase 12	P53778	0.00000	2