Scheme 1.
Synthesis of compounds 2 and 4a–e. Reagents and conditions: (a) 4-bromophenyl-2-chloroacetamide [27], K2CO3, anhydrous CH3CN, reflux, 3–30 h. (b) SOCl2, Et3N, reflux, 8 h. (c) Appropriate alcohol, anhydrous THF, r.t., 1.5–4 h.
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