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Binding modes of neratinib (shown as sticks) into EGFR kinase domain T790M/L858R mutant (pdb: 3W2Q): (A) 3D binding mode, receptor shown as hydrogen bond surface; (B) 2D binding mode showing the covalent bond with Cys797 (yellow sticks) and the hydrogen bond interactions; the figure was generated using Discovery Studio Visualizer (V16.1.0.15350).
