Table 3.

Predictors of the absence of study detailed description in the records of expanded access studies registered with ClinicalTrials.gov.

Variables		Univariate analysis		Multivariate analysis
		Odds ratio (95% CI)a	P value	Adjusted odds ratio (95% CI)a	P value
First posted date
	2020	referent	N/Ab	referent	N/A
	2019	1.02 (0.84-1.23)	.84	N/A	N/A
	2018	1.12 (0.93-1.36)	.22	N/A	N/A
	2017	1.0 (0.81-1.23)	.98	N/A	N/A
Sponsor
	Industry	referent	N/A	referent	N/A
	Nonindustry	0.76 (0.63-0.91)	.003	0.46 (0.19-1.08)	.07
Multicenter study
	No	referent	N/A	referent	N/A
	Yes	1.08 (0.63-0.91)	.41	N/A	N/A
Multinational study
	No	referent	N/A	referent	N/A
	Yes	0.93 (0.89-1.31)	.57	N/A	N/A
US involvement
	No	referent	N/A	referent	N/A
	Yes	0.95 (0.71-1.21)	.66	N/A	N/A
Type of expanded access
	IPc	referent	N/A	referent	N/A
	ISd	0.92 (0.75-1.2)	.33	0.75 (0.36-1.55)	.42
	Tr. IND/Pr.e	0.82 (0.77-1.09)	.02	0.47 (0.23-0.96)	.03

^aFor each variable (first posted date; sponsor; multicenter study; multinational study; US involvement; type of expanded access), odds ratios and 95% CI are shown related to the referent value.

^bN/A: not applicable.

^cIP: individual patients.

^dIS: intermediate-size population.

^eTr. IND/Pr.: Treatment IND/protocol.