Table 4.

Predictors of the absence of information about the central contact person in the records of expanded access studies registered with ClinicalTrials.gov.

Variables		Univariate analysis		Multivariate analysis
		Odds ratio (95% CI)a	P value	Adjusted odds ratio (95% CI)a	P value
First posted date
	2020	referent	N/Ab	referent	N/A
	2019	1.17 (0.97-1.4)	.10	3.62 (0.8-26.08)	.13
	2018	1.26 (1.05-1.51)	.01	11.9 (2.5-89.64)	.004
	2017	1.53 (1.26-1.86)	<.001	21.93 (4.42-172.29)	<.001
Sponsor
	Industry	referent	N/A	referent	N/A
	Nonindustry	0.89 (0.74-1.07)	.19	N/A	N/A
Multicenter study
	No	referent	N/A	referent	N/A
	Yes	0.79 (0.65-0.95)	.01	0.33 (0.13-0.79)	.01
Multinational study
	No	referent	N/A	referent	N/A
	Yes	0.83 (0.64-1.09)	.18	N/A	N/A
US involvement
	No	referent	N/A	referent	N/A
	Yes	1.04 (0.83-1.31)	.73	N/A	N/A
Type of expanded access
	IPc	referent	N/A	referent	N/A
	ISd	0.84 (0.71-1.0)	.05	N/A	N/A
	Tr. IND/Pr.e	0.95 (0.8-1.13)	.54	N/A	N/A

^aFor each variable (first posted date; sponsor; multicenter study; multinational study; US involvement; type of expanded access), odds ratios and 95% CIs are shown related to the referent value.

^bN/A: not applicable.

^cIP: individual patients.

^dIS: intermediate-size population.

^eTr. IND/Pr.: Treatment IND/protocol.