Table 5.

Predictors of the absence of information about the facility location in the records of expanded access studies registered with ClinicalTrials.gov.

Variables		Univariate analysis		Multivariate analysis
		Odds ratio (95% CI)a	P value	Adjusted odds ratio (95% CI)a	P value
First posted date
	2020	referent	N/Ab	referent	N/A
	2019	0.83 (0.68-1.0)	.05	1.0 (0.9-1.1)	.94
	2018	1.0 (0.83-1.21)	.99	1.09 (0.98-1.22)	.10
	2017	0.85 (0.7-1.04)	.12	1.0 (0.9-1.11)	.98
Sponsor
	Industry	referent	N/A	referent	N/A
	Nonindustry	0.89 (0.74-1.07)	.21	0.98 (0.9-1.07)	.65
Multinational study
	No	referent	N/A	referent	N/A
	Yes	0.98 (0.91-1.05)	.55	N/A	N/A
Type of expanded access
	IPc	referent	N/A	referent	N/A
	ISd	0.84 (0.71-1.0)	.05	0.99 (0.91-1.08)	.85
	Tr. IND/Pr.e	0.76 (0.64-0.9)	.001	1.04 (0.96-1.13)	.30

^aFor each variable (first posted date; sponsor; multicenter study; multinational study; US involvement; type of expanded access), odds ratios and 95% CIs are shown related to the referent value.

^bN/A: not applicable.

^cIP: individual patients.

^dIS: intermediate-size population.

^eTr. IND/Pr.: Treatment IND/protocol.