Table 6.

Mediation analysis to evaluate whether the effect of registration date on the risk of the absence of information about the central contact person is mediated by the type of expanded access.

Variable	Estimate	95% CIa	P valueb
ACMEc	0.05	–0.009-0.200	.18
ADEd	0.48	0.08-0.76	.02
TEe	0.53	0.19-0.77	<.001
PMf	0.05	–0.01-0.59	.18

^aQuasi-Bayesian 95% CI.

^bP value as determined by mediation analysis.

^cACME: average causal mediation effect.

^dADE: average direct effect.

^eTE: total effect.

^fPM: proportion mediated.