Table 1.

Total charge of Mpro as a function of pH for the different microstates (MicroS).

	MicroS-1	MicroS-2	MicroS-3	MicroS-4	MicroS-5	MicroS-6	MicroS-7	MicroS-8	MicroS-9	MicroS-10	Average Value
pH3	38	40	41	42	43	43	42	41	39	41	41 ± 2
pH4	24	27	20	22	23	20	26	22	22	22	23 ± 2
pH5	7	4	8	6	2	5	1	5	2	7	5 ± 2
pH6	−6	−5	−4	−4	−5	−6	−8	−7	−4	−6	−(5.5 ± 1.4)
pH7	−8	−9	−9	−8	−8	−7	−8	−9	−9	−9	−(8.4 ± 0.7)