Table 3.
Drugs with high AUROC-impacted value.
| ATCa | AUROCb loss (%) (95% CI) | ORc (95% CI) | Patient number | Age- and gender-matched OR |
| A05BA (liver therapy) | 1.35 (1.27-1.42) | 14.26 (13.29-15.31) | 4353 | 12.03 (11.3-12.8) |
| A02AF (antacids with antiflatulents) | 1.2 (1.19-1.21) | 10.38 (9.72-11.08) | 4707 | 11.87 (11.1-12.7) |
| B05BA (solutions for parenteral nutrition) | 0.77 (0.67-0.87) | 5.18 (4.71-5.69) | 1873 | 6.07 (5.5-6.7) |
| A02AB (aluminum compounds) | 0.63 (0.56-0.76) | 3.27 (3.04-3.51) | 3335 | 3.31 (3.1-3.6) |
| R06AX12 (antihistamine, treatment of allergy) | 0.57 (0.42-0.65) | 31.78 (26.28-38.43) | 1008 | 37.58 (31-45.6) |
| B05XC (vitamins) | 0.56 (0.52-0.59) | 5.92 (5.19-6.76) | 942 | 6.38 (5.6-7.3) |
| A11JC (vitamins, other combinations) | 0.5 (0.09-0.98) | 13.68 (11.7-15.98) | 890 | 14.46 (12.4-16.8) |
| C03DA (antimineralocorticoid) | 0.45 (0.44-0.45) | 6.42 (5.73-7.19) | 1286 | 7.2 (6.4-8.1) |
| A05AA (bile therapy) | 0.42 (0.27-0.51) | 14.13 (12.28-16.25) | 1115 | 11.39 (10.1-12.9) |
| A11BA (multivitamins) | 0.39 (0.21-0.67) | 7.47 (5.48-10.18) | 176 | 7.78 (5.8-10.5) |
| A11AA (multivitamins with minerals) | 0.36 (0.03-0.58) | 7.7 (6.22-9.52) | 379 | 6.92 (5.7-8.4) |
| B02BA (vitamin K) | 0.25 (0.03-0.6) | 7.58 (5.61-10.23) | 189 | 6.53 (5-8.6) |
| D10AF (treatment of acne) | 0.48 (0.15-1) | 0.4 (0.36-0.46) | 3017 | 0.72 (0.6-0.8) |
| G03DC (progestogens) | 0.36 (0.08-0.53) | 0.39 (0.33-0.46) | 1809 | 0.91 (0.8-1.1) |
| D10AX03 (azelaic acid, antiacne) | 0.31 (0.09-0.57) | 0.36 (0.26-0.5) | 503 | 0.72 (0.5-1) |
aATC: Anatomical Therapeutic Chemical (classification system).
bAUROC: area under the receiver operating curve.
cOR: odds ratio.