Table 2.

Expression Values of LPARs After Gintonin Administration

Receptor		Organs
		Brain		Heart		Lung		Liver		Kidney
		Mean ± SEM	Fold changes	Mean ± SEM	Fold changes	Mean ± SEM	Fold changes	Mean ± SEM	Fold changes	Mean ± SEM	Fold changes
LPA1	Con	0.045 ± 0.011	2.4 ↓	0.004 ± 0.001	32 ↑	0.001 ± 0.000	39 ↑	ND	ND	0.071 ± 0.060	0 ↓
	GT	0.018 ± 0.006∗		0.143 ± 0.072∗		0.044 ± 0.015∗		ND		0.000 ± 0.000
LPA2	Con	0.040 ± 0.037	1.8 ↓	0.090 ± 0.076	3 ↑	0.116 ± 0.041	2.3 ↓	0.618 ± 0.382	0 ↓	0.043 ± 0.024	0 ↓
	GT	0.020 ± 0.020		0.278 ± 0.239		0.050 ± 0.050		0.000 ± 0.000		0.000 ± 0.000
LPA3	Con	0.039 ± 0.037	5 ↑	0.022 ± 0.018	1.4 ↑	0.085 ± 0.056	4.5 ↑	0.329 ± 0.289	1.4 ↑	0.329 ± 0.289	1.4 ↑
	GT	0.200 ± 0.184		0.030 ± 0.030		0.382 ± 0.280		0.478 ± 0.294		0.478 ± 0.294
LPA4	Con	0.168 ± 0.092	1.8 ↑	0.135 ± 0.082	3.9 ↑	0.019 ± 0.010	4 ↑	ND	ND	0.150 ± 0.150	0 ↓
	GT	0.302 ± 0.147		0.529 ± 0.332		0.077 ± 0.028∗		ND		0.000 ± 0.000
LPA5	Con	0.002 ± 0.001	0 ↓	0.003 ± 0.002	0 ↓	0.004 ± 0.004	25 ↑	ND	ND	ND	ND
	GT	0.000 ± 0.000		0.000 ± 0.000		0.094 ± 0.049∗		ND		ND
LPA6	Con	1.176 ± 0.344	8.7 ↓	6.597 ± 0.801	3.4 ↓	3.952 ± 0.882	1.4 ↓	9.589 ± 1.709	8.5 ↑	3.339 ± 0.074	1.1 ↓
	GT	0.135 ± 0.057∗		1.918 ± 0.442∗		2.777 ± 1.397		81.12 ± 11.000∗		2.925 ± 1.091

Receptor		Organs
		Spleen		Small Intestine		Colon		Testis
		Mean ± SEM	Fold changes	Mean ± SEM	Fold changes	Mean ± SEM	Fold changes	Mean ± SEM	Fold changes
LPA1	Con	0.001 ± 0.001	40 ↑	0.022 ± 0.020	14 ↑	0.024 ± 0.021	1.1 ↓	0.080 ± 0.032	3 ↑
	GT	0.073 ± 0.028∗		0.314 ± 0.167∗		0.021 ± 0.010		0.243 ± 0.222
LPA2	Con	ND	ND	0.677 ± 0.085	1.5 ↓	ND	ND	0.056 ± 0.045	0 ↓
	GT	ND		0.427 ± 0.422		ND		0.000 ± 0.000
LPA3	Con	0.401 ± 0.236	1.5 ↓	0.125 ± 0.087	5.1 ↑	0.145 ± 0.126	6.7 ↓	0.377 ± 0.212	1.8 ↑
	GT	0.252 ± 0.252		0.635 ± 0.464		0.022 ± 0.017		0.698 ± 0.365
LPA4	Con	0.035 ± 0.017	9 ↑	0.001 ± 0.001	581 ↑	ND	ND	0.016 ± 0.016	15 ↑
	GT	0.324 ± 0.070		0.499 ± 0.257∗		0.595 ± 0.203∗		0.243 ± 0.122∗
LPA5	Con	0.056 ± 0.054	0 ↓	0.121 ± 0.105	1.4 ↑	ND	ND	0.109 ± 0.081	0 ↓
	GT	0.000 ± 0.000		0.169 ± 0.103		ND		0.000 ± 0.000
LPA6	Con	0.392 ± 0.045	1.8 ↑	0.535 ± 0.079	4.8 ↑	0.612 ± 0.067	2.6 ↑	0.334 ± 0.060	11.8 ↑
	GT	0.723 ± 0.476		2.595 ± 0.887∗		1.604 ± 0.765		3.939 ± 1.066∗

ND: Not detected in two groups.

↓: Tendency to decrease in gintonin-treated group.

↑: Tendency to increase in gintonin-treated group.

∗p < 0.05 vs control.