Table 1.

Anti-cholinesterase (AChE and BChE) potential of synthesized compounds 5a–k.

Compound	Substituent			Acetylcholinesterase(AChE)	Butyrylcholinesterse(BChE)
	R1	R2	R3	IC50 ± SEM (μM)/%inhibition
5a	H	H	ethylmorpholine	2.95 ± 0.24	3.32%
5b	OMe	H	ethylmorpholine	0.12 ± 0.02	8.12%
5c	H	OMe	ethylmorpholine	5.53 ± 0.11	1.33%
5d	H	Me	ethylmorpholine	0.55 ± 0.01	1.52%
5e	H	Cl	ethylmorpholine	10.5 ± 0.16	1.88%
5f	H	H	Ph	23.2 ± 1.28	4.47%
5g	OMe	H	Ph	34.2 ± 1.02	11.3 ± 0.67
5h	Me	H	Ph	49.3 ± 2.49	32.6%
5i	H	OMe	Ph	60.9 ± 6.57	24.0%
5j	H	Me	Ph	46.5 ± 3.12	16.8%
5k	H	Cl	Ph	47.1 ± 1.45	20.3%
Galantamine	―	―	―	0.62 ± 0.01	0.87 ± 0.03