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Reagents and conditions: (a) BnBr, K2CO3, acetone, reflux; (b) ethylene glycol, p-TsOH.H2O, toluene, reflux; (c) Ac2O, reflux; (d) TrocCl, K2CO3, 1,1,2,2-tetrachloroethane, 140 °C; (e) KOH aq., DMSO, 110 °C; (f) cyclopropylcarbonyl chloride, Et3N, CH2Cl2, rt; (g) HCl, MeOH, 80 °C; (h) 10% Pd/C, H2, MeOH, no further purification of the obtained crude; (i) 2-(4-chlorophenyl)-3-hydroxy-prop-2-enal, ammonium acetate, AcOH, reflux.
