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. 2021 Nov 2;26(21):6640. doi: 10.3390/molecules26216640

Table 2.

IC50 values of compounds 2b, 2h, and Selegiline against MAO-B.

Compounds MAO-B % Inhibition IC50
(µM)
Selectivity Index
10−3 M 10−4 M 10−5 M 10−6 M 10−7 M 10−8 M 10−9 M
2b 91.625 ± 1.652 87.357 ± 1.388 81.547 ± 1.722 74.951 ± 1.634 66.379 ± 0.975 41.513 ± 0.856 25.820 ± 0.765 0.042 ± 0.002 >23.812
2h 90.412 ± 1.602 84.362 ± 1.325 80.792 ± 1.045 72.188 ± 1.388 64.970 ± 1.107 42.826 ± 0.948 30.945 ± 0.782 0.056 ± 0.002 >17.857
Selegiline 99.387 ± 1.385 95.629 ± 1.456 86.205 ± 1.200 78.324 ± 1.108 66.871 ± 1.056 42.875 ± 0.865 16.748 ± 0.596 0.037 ± 0.001