Table 2.
Compounds | MAO-B % Inhibition | IC50 (µM) |
Selectivity Index | ||||||
---|---|---|---|---|---|---|---|---|---|
10−3 M | 10−4 M | 10−5 M | 10−6 M | 10−7 M | 10−8 M | 10−9 M | |||
2b | 91.625 ± 1.652 | 87.357 ± 1.388 | 81.547 ± 1.722 | 74.951 ± 1.634 | 66.379 ± 0.975 | 41.513 ± 0.856 | 25.820 ± 0.765 | 0.042 ± 0.002 | >23.812 |
2h | 90.412 ± 1.602 | 84.362 ± 1.325 | 80.792 ± 1.045 | 72.188 ± 1.388 | 64.970 ± 1.107 | 42.826 ± 0.948 | 30.945 ± 0.782 | 0.056 ± 0.002 | >17.857 |
Selegiline | 99.387 ± 1.385 | 95.629 ± 1.456 | 86.205 ± 1.200 | 78.324 ± 1.108 | 66.871 ± 1.056 | 42.875 ± 0.865 | 16.748 ± 0.596 | 0.037 ± 0.001 | – |