Table 2.
Role of nanofiber materials in various tissue engineering applications.
| Materials | Property and Role | Applications | Ref. |
|---|---|---|---|
| Platelet-rich fibrin loaded/chitosan core-shell nanofibrous scaffold | Helps in protecting and preserving the biomolecules from direct contact with solvents and changing microenvironment during in vitro studies and in vivo implantation. | Bone tissue engineering | [124] |
| Polycaprolactone/polyvinylpyrrolidone nanofibers | Attachment and proliferation of osteoblasts in vitro while potentially enhancing the cell–cell interactions and cell migration necessary for bone healing | Bone regeneration | [121] |
| Polylactic acid glycolic acid/silk fibroin membranes loaded with artemisinin | Polylactic acid glycolic acid can provide good mechanical properties, and SF can improve the biocompatibility and drug-release property of dressings. ART was loaded on membranes as an anti-inflammatory agent | Wound dressing | [130] |
| Poly-ε-caprolactone (PCL)/whitlockite (WH) nanofiber membrane | This biomimetic nanofiber membrane combines the positive osteogenic differentiation ability and angiogenic ability of calcium phosphate materials, and is expected to be used for artificial periosteum. | Periosteal Regeneration | [123] |
| Poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel nanofibers | Nanofiber alignment played a supporting role on cell alignment, with parallel-oriented fibers further promoting cell orientation with respect to the underlying uniaxial wrinkle direction while perpendicular-oriented fibers locally de-aligned the cells. | In vitro cell screening and in vivo tissue regeneration | [131] |
| Gelatin methacryloyl-coated, 3D expanded nanofiber scaffolds | These scaffolds seeded with various types of cells, including dermal fibroblasts, bone marrow-derived mesenchymal stem cells, and human neural stem/precursor cells to form 3D complex tissue constructs. | Tissue regeneration | [132] |
| Poly(l-lactide-co-ε-caprolactone)/silk fibroin scaffolds | Supports in mimicking the microarchitecture of native cartilage. | Cartilage regeneration | [122] |
| Polyamide-6/chitosan nanofibrous membranes | The nanofibrous membrane provides high toughness and good mechanical properties (tensile strength 1.41 ± 0.18 MPa and elastic modulus 7.15 ± 1.09 MPa) and supports bioactivity, biocompatibility and osteoconductivity. | Bone regeneration | [133] |
| Poly(4-hydroxybutyrate) nanofiber membrane | The electrospun P4HB membrane could facilitate fibroblasts infiltration in the porous structure, with a proper degradation rate that matches the new tissue formation during dural re-construction. | Tissue regeneration | [126] |
| Poly (l/dl-lactic acid nanofiber) | When functionalized with a chemotactic agent such as the SDF-1α/CXCL12 chemokine, an in-situ increment of migration signaling on the surface to drive cells through the fibers was achieved | Neural Regeneration | [129] |