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. 2021 Nov 2;26(21):6644. doi: 10.3390/molecules26216644

Table 5.

P. aeruginosa tobramycin’s MIC reduction in the presence of double the concentrations of o-CH3 and p-CH3 derivatives.

Compound Concentration (µg/mL)
Compound 0 10 20 40 80 160 320 P. aeruginosa Strain
o-CH3 256 32 16 8 8 8 8 PA7
p-CH3 256 128 64 64 32 32 16
o-CH3 0.5 0.06 0.06 0.06 0.06 0.06 0.06 PAO1
p-CH3 0.5 0.25 0.25 0.25 0.25 0.25 0.25
o-CH3 0.5 0.25 0.25 0.125 0.125 0.125 0.125 PA14
p-CH3 0.5 0.125 0.125 0.125 0.125 0125 0.125