Figure 2.

TEP of a normal skin is generated by Na/K/ATPase pump where the Na⁺ ions are continuously pumped into skin. The TEP is measured to be 10-60 mV/mm in which the anucleated stratum corneum is relatively negative compared to the stratum basale as shown in subfigure (a). Subfigure (b) shows the current of the injury when the skin is wounded. As the TEP is disturbed during an injury, the center of a wound experiences a drop in potential, making it more negatively-charged comssspared to the wound edges. The potential difference between the edges and center of a wound generates the current of injury of 150–200 mV/mm which directs the most skin cells to migrate to the center of the wound in the healing process and closes up the wound.