Table 1.
Variables and observed responses in BBD.
| Formulation Code | Factors Combinations at Different Levels | Response Variables | ||||
|---|---|---|---|---|---|---|
| X1 = Chitosan (% w/v) | X2= Sodium Alginate (% w/v) | X3 = Calcium Chloride (% w/v) | Y1 = Particle Size (nm) | Y2 = Polydispersity Index (%) | Y3 = Zeta Potential (mV) | |
| BNP1 | 0.02 | 0.3 | 0.1 | 248.3 ± 0.02 | 0.541 ± 0.02 | −20.8 ± 2.3 |
| BNP2 | 0.04 | 0.3 | 0.1 | 270 ± 3.3 | 0.414 ± 0.05 | −20.9 ± 2.3 |
| BNP3 | 0.06 | 0.3 | 0.1 | 314 ± 6.5 | 0.621 ± 0.03 | −25.4 ± 2.6 |
| BNP4 | 0.05 | 0.3 | 0.1 | 314.2 ± 9.9 | 0.568 ± 0.01 | −13.6 ± 3.1 |
| BNP5 | 0.08 | 0.3 | 0.1 | 341.2 ± 2.3 | 0.761 ± 0.08 | −30.8 ± 2.3 |
| BNP6 | 0.02 | 0.3 | 0.2 | 278.2 ± 4.6 | 0.496 ± 0.06 | −21.8 ± 2.7 |
| BNP7 | 0.04 | 0.3 | 0.2 | 341.2 ± 5.7 | 0.521 ± 0.05 | −22.8 ± 2.9 |
| BNP8 | 0.02 | 0.1 | 0.1 | 347.5 ± 4.8 | 0.376 ± 0.04 | −27.8 ± 1.6 |
| BNP9 | 0.02 | 0.2 | 0.1 | 246.1 ± 5.3 | 0.295 ± 0.07 | −25.8 ± 1.9 |
| BNP10 | 0.02 | 0.4 | 0.1 | 323.3 ± 6.2 | 0.504 ± 0.03 | −19.8 ± 2.1 |
| BNP11 | 0.02 | 0.5 | 0.1 | 260.4 ± 2.9 | 0.491 ± 0.02 | −18.4 ± 1.6 |
| BNP12 | 0.02 | 0.6 | 0.1 | 361.5 ± 4.2 | 0.594 ± 0.04 | −30.8 ± 1.8 |
| BNP13 | 0.10 | 0.5 | 0.1 | 290.2 ± 8.2 | 0.435 ± 0.03 | −18.6 ± 3.0 |
| BNP14 | 0.04 | 0.5 | 0.1 | 220.52 ± 3.1 | 0.311 ± 0.01 | −15.1 ± 1.6 |
| BNP15 | 0.08 | 0.5 | 0.1 | 218.6 ± 5.1 | 0.672 ± 0.012 | −16.1 ± 1.8 |
| BNP16 | 0.06 | 0.5 | 0.1 | 334.1 ± 2.9 | 0.446 ± 0.06 | −11.9 ± 2.9 |
| BNP17 | 0.02 | 0.5 | 0.1 | 253.8 ± 6.1 | 0.582 ± 0.02 | −12.7 ± 3.5 |