Table 1.

Search strategy in each database.

Database	Search Strategy
PubMed Medline	(multiple sclerosis[mh] or multiple sclerosis[tiab] or “multiple sclerosis”[tiab]) AND (virtual reality[mh] OR virtual reality[tiab] OR virtual reality exposure therapy[mh] OR virtual reality exposure therapy[tiab] OR “virtual reality”[tiab] OR videogames[tiab] OR exergames[tiab] OR serious games[tiab]) AND (fatigue[mh] OR “fatigue”[tiab] OR muscle fatigue[mh] OR muscle fatigue[tiab] OR quality of life[mh] OR quality of life[tiab])
SCOPUS	(TITLE-ABS-KEY (“multiple sclerosis” OR “esclerosis múltiple”) AND TITLE-ABS-KEY (“virtual reality” OR “videogames” OR “exergames” OR “serious games” OR “games”) AND TITLE-ABS-KEY (“fatigue” OR “quality of life”))
Web of Science	(*multiple sclerosis* OR *esclerosis múltiple*) (Topic) and (*virtual reality* OR *exergames* OR * videogames* OR *serious games* OR *games*) (Topic) and (*fatigue* OR *quality of life*) (Topic)
PEDro	(multiple sclerosis) and (virtual reality)