TABLE 5.
Typeabilities and DIs of PCR-RFLP analysis of ureAB (2.4 kb) digested with HaeIII, ureC (820 or 1,100 bp) digested with Sau3A, or ureC (820 bp or 1.1 kbp) digested with HhaI determined with data from selected studies
| Gene and enzyme | Authors (reference no.) | No. of unrelated patients | Typeabilitya | No. of typesb | DI |
|---|---|---|---|---|---|
| ureAB (2.4 kb) digested with HaeIII | Akopyanz et al. (4) | 60 | 60/60 | 27 | UCc |
| Foxall et al. (20) | 21 | 21/21 | 10 | 0.87 | |
| Hurtado and Owen (29) | 44 | 44/44 | 30 | 0.98 | |
| Romero Lopez et al. (56) | 13 | 13/13 | 12 | 0.99 | |
| Owen et al. (52) | 12 | 12/12 | 10 | 0.97 | |
| Salaün et al. (58) | 39 | 39/39 | 26 | 0.98 | |
| Wang et al. (74) | 13 | 13/13 | 10 | 0.97 | |
| Burucoa et al. (this study) | 40 | 40/40 | 20 | 0.96 | |
| Pooled results | 242/242 (100) | 0.96 | |||
| ureC (820 bp) digested with Sau3A | Stone et al. (61) | 72 | 72/72 | 42 | UC |
| 22d | 10 | 0.86 | |||
| Shortridge et al. (60) | 81 | 81/81 | 44 | UC | |
| 18d | 8 | 0.89 | |||
| Stone et al. (62) | 83 | 83/83 | 12 | 0.86 | |
| Pooled results | 236/236 (100) | 0.86 | |||
| ureC (1.1 kb) digested with Sau3A | Burucoa (this study) | 40 | 40/40 | 27 | 0.97 |
| ureC (820 bp) digested with HhaI | Fujimoto et al. (22) | 25 | 25/25 | 10 | 0.86 |
| Stone et al. (61) | 72 | 72/72 | 42 | UC | |
| 22d | 8 | 0.70 | |||
| Shortridge et al. (60) | 81 | 81/81 | 44 | UC | |
| 18 | 5 | 0.53 | |||
| Stone et al. (62) | 83 | 83/83 | 12 | 0.71 | |
| Pooled results | 261/261 (100) | 0.71 | |||
| ureC (1.1 kb) digested with HhaI | Li et al. (36) | 19 | 19/19 | 11 | 0.94 |