Table 2.
Relative hepatic lipid content of the study groups from the CDAA murine model at 32 weeks
| Parameter | CDAA WT vs CSAA WT | CDAA Ripk3−/ − vs CDAA WT | CSAA Ripk3−/ − vs CSAA WT | CDAA Ripk3−/ − vs CSAA Ripk3−/− | ||||
| Fold change | P value | Fold change | P value | Fold change | P value | Fold change | P value | |
| FA | 1.09 | ns | 1.05 | ns | 0.85 | ns | 1.34 | 0.04 |
| SFA | 1.22 | ns | 0.95 | ns | 0.80 | 0.06 | 1.45 | 0.01 |
| MUFA | 0.92 | ns | 1.22 | ns | 0.98 | ns | 1.14 | ns |
| PUFA | 1.12 | ns | 1.02 | ns | 0.81 | ns | 1.41 | 0.03 |
| FA omega-3 | 1.06 | ns | 1.06 | ns | 0.74 | 0.03 | 1.52 | 0.01 |
| FA omega-6 | 1.20 | ns | 1.90 | ns | 0.75 | 0.08 | 1.43 | 0.03 |
| FA omega-9 | 0.90 | ns | 1.22 | ns | 1.08 | ns | 1.01 | ns |
| DG | 1.08 | ns | 1.42 | <0.001 | 1.41 | 0.05 | 1.09 | ns |
| Saturated DG | 1.16 | ns | 1.69 | <0.001 | 1.93 | 0.02 | 1.02 | ns |
| TG | 1.57 | 0.01 | 1.18 | ns | 1.13 | ns | 1.64 | <0.001 |
| Saturated TG | 1.71 | 0.01 | 1.34 | ns | 1.57 | 0.01 | 1.46 | 0.04 |
| ChoE | 1.13 | ns | 1.27 | ns | 1.04 | ns | 1.37 | 0.02 |
| PC | 0.94 | ns | 0.92 | ns | 0.78 | <0.001 | 1.10 | ns |
| PE | 1.42 | 0.01 | 0.91 | ns | 0.80 | <0.001 | 1.62 | 0.001 |
| Cer | 1.01 | ns | 1.06 | ns | 0.83 | 0.04 | 1.27 | 0.01 |
| SM | 1.06 | ns | 0.96 | ns | 0.73 | 0.001 | 1.39 | <0.001 |
| MUFA+PUFA/SFA | 0.86 | 0.04 | 1.14 | 0.03 | 1.08 | ns | 0.91 | ns |
| PUFA/MUFA | 1.22 | 0.04 | 0.80 | 0.03 | 0.81 | 0.02 | 1.20 | 0.03 |
| Omega-6/omega-3 | 1.19 | 0.04 | 0.81 | 0.03 | 1.03 | ns | 0.94 | ns |
| TG/DG | 1.42 | 0.001 | 0.84 | 0.04 | 0.83 | 0.07 | 1.45 | 0.001 |
| SM+DG/Cer+PC | 1.12 | 0.01 | 1.19 | 0.001 | 1.21 | 0.01 | 1.10 | ns |
| FA 16:0/18:2n-6 | 1.06 | ns | 0.99 | ns | 1.18 | 0.04 | 0.90 | ns |
| FA 16:1n-7/16:0 | 0.58 | ns | 2.39 | <0.001 | 1.72 | 0.01 | 0.94 | ns |
| FA 18:0/16:0 | 1.14 | ns | 0.78 | ns | 0.97 | ns | 0.92 | ns |
| FA 18:1n-9/18:0 | 0.77 | ns | 1.54 | 0.01 | 1.16 | ns | 1.02 | ns |
| FA 18:3n-6/18:2n-6 | 1.66 | <0.001 | 0.78 | <0.01 | 1.03 | ns | 1.25 | 0.01 |
| FA 20:4n-3/20:3n-3 | 0.69 | 0.001 | 1.50 | <0.001 | 1.01 | ns | 1.02 | ns |
| FA 20:5n-3/20:4n-3 | 1.56 | 0.01 | 0.71 | 0.02 | 0.93 | ns | 1.20 | ns |
| FA 22:5n-3/20:5n-3 | 1.48 | <0.01 | 0.87 | ns | 1.00 | ns | 1.28 | <0.01 |
Cer, ceramides; ChoE, cholesteryl esters; DG, diglycerides; FA, fatty acids; MUFA, monounsaturated fatty acids; ns, non-significant; PC, phosphatidylcholines; PE, phosphatidylethanolamines; PUFA, polyunsaturated fatty acids; SFA, saturated fatty acids; SM, sphingomyelins; TG, triglycerides.