. 2021 Sep 30;26(6):e12894. doi: 10.1111/anec.12894

TABLE 1.

Clinical applications of ECG heterogeneity

	Cohort	Publication	Adjusted Odds Ratio	AUC
SCD and cardiac death risk assessment in resting 12‐lead ECG	Health Survey 2000; general population, n = 5618	Kenttä et al., ²⁰¹⁶	1.7–3.2 for SCD; 2.1–3.5 for cardiac death	NR
	Cardiomyopathy during EP study, single center, n = 120	Tan et al., ²⁰¹⁷	NR	0.71 (3‐dimensional)
	Emergency department, single center, 90‐day mortality, n = 100	Monteiro et al., ²⁰²¹	Women: 121.4; Men: 2.9	0.933 for women 0.573 for men
Arrhythmia risk assessment in heart failure patients with reduced LVEF	Hospitalized patients with decompensated heart failure in PRECEDENT trial	Nearing et al., ²⁰¹²	NR	NR
	CRT patients, single center, n = 155	Bortolotto et al., ²⁰²⁰	19.1–43.0 for RWH, 9.5–24.0 for TWH in predicting super‐response to CRT in patients with non‐LBBB	0.891 for RWH in predicting super‐response to CRT in patients with non‐LBBB
	ANTHEM‐HF Pilot study, n = 25	Nearing et al., ²⁰²¹	NR	NR
Detection of clinically significant coronary stenosis	Referred for ETT or pharmacological stress testing with dipyridamole, single center, n = 137	Silva et al., ²⁰²⁰	ETT = 5.26; dipyridamole stress = 30.22	ETT = 0.737; dipyridamole stress = 0.818
	Referred for pharmacological stress testing with regadenoson, single center, n = 103	Araujo Silva et al., ²⁰²⁰	Men = 7.3; women = 4.5	Men = 0.79; women = 0.71

Abbreviations: CRT, cardiac resynchronization; EP, electrophysiologic; ETT, exercise tolerance testing; non‐LBBB, non‐left bundle branch block; NR, not reported; RWH, R‐wave heterogeneity; SCD, sudden cardiac death; TWH, T‐wave heterogeneity.